ANTI-INFECTIVES Antibacterials Cephalosporins

AMH 2022 section 5.1.3

Active ingredients (generic names)

CEFALEXIN (sef-a-lex-in)

CEFAZOLIN (ce-faz-o-lin)

CEFTAZIDIME (cef-ta-zi-din)

CEFTRIAXONE (cef-tri-ax-own)

CEFUROXIME (cef-uro-xim)

Capsules and tablets

Mixture.

medicine - injection IV.jpg

Other cephalosporins

Not included in this monograph — see AMH for information:

  • Cefepime
  • Cefotaxime
  • Cefoxitin
  • Ceftaroline
  • Ceftolozane
What it is used for
  • Lots of infections — gonorrhoea, kidney infections, mastitis, melioidosis, meningitis, pneumonia, septicaemia, skin and soft tissue infections, urinary tract infection (UTIs)
  • Sepsis (ceftriaxone)
  • Chronic suppurative lung disease (CSLD) in children — if acute episode (cefuroxime)

Doses: Cefalexin, Cefazolin, Ceftazidime, Ceftriaxone, Cefuroxime

How it works
  • Antibiotic that stops bacteria's cell wall from growing
  • Different germs need different antibiotics. If not sure which one to use — check with doctor
Side effects
  • Serum sickness-like reaction — rash,  swollen glands, sore joints
  • Anaphylaxis rare — but consider if trouble breathing

Diarrhoea

Nausea

Rash

Anaphylaxis — severe allergic reaction

 

Warnings
  • Person who is allergic to penicillin may also be allergic to cephalosporins

Kidney trouble

Tell the patient
  • Take all the medicine — makes sure all the germs are gone and the infection doesn't come back
  • If mixture not kept in fridge — use-by/expiry date will be sooner and it won't work as well

Return to clinic straight away 

if you get rash, swollen glands, sore joints (serum sickness-like reaction)

Store in fridge
(not freezer)

— if you don’t the use-by/expiry date will be sooner and it won't work as well

Finish medicine
— even if you feel better

Warning stickers: Cefaclor Axref-slash icon, Bxref-slash icon Medicine mixture (cefalexin) 6xref-slash icon, 7axref-slash icon

Check
  • Always have anaphylaxis kit with adrenaline (epinephrine) ready when giving ceftriaxone or cefazolin injections
  • Follow-up when antibiotic finished to make sure infection is gone. If not — medical consult

Making mixture

Make sure right amount of clean water added to dry powder