ANTI-INFECTIVES Antibacterials Penicillins

AMH 2022 section 5.1.8

Active ingredients (generic names)

AMOXICILLIN (am-ox-i-sil-in)

AMPICILLIN (am-pi-sil-in)

BENZATHINE BENZYLPENICILLIN (benz-a-thine benz-el-pen-i-sil-in gee)

BENZYLPENICILLIN (benz-el-pen-i-sil-in)

DICLOXACILLIN (di-clox-a-sil-in)

FLUCLOXACILLIN (flu-clox-a-sil-in)

PHENOXYMETHYLPENICILLIN (fen-oxi-methal-pen-i-sil-in)

PROCAINE BENZYLPENICILLIN (procaine penicillin) (pro-cane benz-el-pen-i-sil-in)

AMOXICILLIN + CLAVULANIC ACID (am-ox-i-sil-in klav-u-lan-ic a-sid)

Capsules and tablets

Mixture.

medicine - injection IV.jpg

medicine - injection IM.jpg

Other penicillin combinations

Not included in this monograph — see AMH for information:

  • Piperacillin + tazobactam (eg PiperTaz, PiptazTazocin EF)
What it is used for
  • Different types of bacterial infections

Doses:  Antibiotics doses table —  CARPA STM, WBM

How it works
  • Kills bacteria sensitive to penicillin — stops cell wall from growing
  • Different germs need different antibiotics. If not sure which one to use — check with doctor
Side effects

Pain at injection site with benzathine benzylpenicillin

Diarrhoea

Nausea

Rash

Anaphylaxis — severe allergic reaction

 

 

Warnings
  • About 1 in 10 people are allergic to penicillin
    • Consider allergy if rash
  • Anaphylaxis is rare — but consider if trouble breathing 

 

Rash

Kidney trouble

Tell the patient
  • Rheumatic fever needs regular long-term treatment with benzathine benzylpenicillin to prevent heart damage or stop it getting worse. Doctor will tell you when you can stop
  • Take all the medicine — makes sure all the germs are gone and the infection doesn't come back

Take on empty stomach
(dicloxacillin, flucloxacillin, phenoxymethylpenicillin)

Store in fridge
(not freezer)

If any left after 2 weeks — return it to clinic

Finish medicine
— even if you feel better

Warning stickers: Medicine mixtures 6xref-slash icon, 7axref-slash icon Dicloxacillin, flucloxacillin, phenoxymethylpenicillin 3axref-slash icon or 3bxref-slash icon Amoxicillin + clavulanic acid 13xref-slash icon, Fxref-slash icon

Check
  • Must have anaphylaxis kit with adrenaline (epinephrine) ready when giving penicillin by injection
  • Follow-up when antibiotic treatment finished to make sure infection is gone. If not — medical consult

Making mixture

Make sure right amount of clean water added to dry powder

Blood test

if using for more than 10 days at a high dose — kidney function (UEC), liver function tests (LFT), FBC