ANTI-INFECTIVES Drugs for gout Other drugs for gout

AMH 2022 section 15.2.2

Active ingredients (generic names)

PROBENECID (pro-ben-a-sid)

Tablets

What it is used for

Helps antibiotics work better in treatment of

Can use for long-term treatment of gout

Doses

How it works
  • Reduces elimination of some acidic medicines (eg penicillins, cephalosporins) by the kidneys — so more antibiotic stays in body and works for a longer time
  • Increases removal of uric acid by the kidneys — reducing risk of gout attack
Side effects

Rash

Nausea and vomiting

Headache

Dizzy

Kidney stones

Warnings
  • Do not start (or restart) use during a gout attack
    • If person already taking regularly — can continue to use

Kidney stones

Pregnant

Breastfeeding

Children under 2 years

Interactions — Do not use together without medical consult
  • Probenecid interacts with a lot of different medicines — always check with doctor or pharmacist before adding another medicine

Tell the patient
  • Do not take more than 1 aspirin a day unless doctor tells you to

Take with food or milk — so medicine doesn’t make you feel sick

Drink lots of water — helps stop build up of uric acid, can prevent kidney stones

Warning stickers: 10axref-slash icon, Bxref-slash icon

Check

Blood test

Regular checks for kidney function (UEC), FBC