Ondansetron | RPHCM

GASTROINTESTINAL — Antiemetics — 5HT3 antagonists

AMH 2022 section 12.3.2

Active ingredients (generic names)	ONDANSETRON (on-dan-set-ron) Other 5HT3 antagonists Not included in this monograph — see AMH for information: Granisetron Palonosetron Tropisetron MB-ONDANSETRON.pdf
What it is used for	Nausea and vomiting Persistent vomiting with diarrhoea (children) Doses
How it works	Stops nausea and vomiting by blocking central and peripheral 5HT3 receptors (a type of serotonin receptor)
Side effects	Constipation Headache Dizzy
Warnings	Breastfeeding (OK for 1–2 doses) Children under 2 years Liver trouble — use lower dose Interactions — Do not use together without medical consult ONDANSETRON with Apomorphine Rifampicin Tramadol — reduces analgesic effect of tramadol
Tell the patient	If too nauseous to swallow tablets or medicine mixture — dissolve wafer on the tongue
Check	For cause of nausea