ANTI-INFECTIVES Antibacterials Other antibacterials

AMH 2022 section 5.1.13

Active ingredients (generic names)

TRIMETHOPRIM (tri-meth-o-prim)

TRIMETHOPRIM + SULFAMETHOXAZOLE (tri-meth-o-prim + sul-fa-meth-ox-a-zol)

Also known as:  co-trimoxazole

Common brands include: Resprim, Septrin

Tablets

Mixture.

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What it is used for

Trimethoprim

  • Respiratory infections, UTIs, prostatitis

Trimethoprim + sulfamethoxazole

Dosestrimethoprim + sulfamethoxazole

How it works
  • Antibiotic that stops bacteria from making folate, which is important for bacteria’s growth
  • Different germs need different antibiotics. If not sure which one to use — check with doctor
Side effects

Nausea and vomiting

Itchy rash

Fever

Warnings

Pregnant

Babies under 6 weeks

Kidney trouble

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Liver trouble
(severe)

Old people

Interactions — Do not use together without medical consult

TRIMETHOPRIM with

  • Methotrexate
  • Phenytoin

TRIMETHOPRIM + SULFAMETHOXAZOLE with

  • Methotrexate
  • Phenytoin
  • Warfarin
Tell the patient
  • Take all the medicine — makes sure all the germs are gone and the infection doesn't come back 

Take at night
(trimethoprim)

Finish medicine
— even if you feel better

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Return to clinic straight away 

if you get a sore throat, fever, troublesome rash, cough, difficulty breathing, joint pain, dark urine or pale stools

Drink lots of water

Take with food
(trimethoprim + sulfamethoxazole)

Keep out of the sun
(trimethoprim + sulfamethoxazole)

Warning stickers: Trimethoprim + sulfamethoxazole 8xref-slash icon, Bxref-slash icon

Check
  • Follow-up when antibiotic treatment finished to make sure infection is gone. If not — medical consult

Blood test

If taking trimethoprim + sulfamethoxazole for a long time — FBC, kidney function (UEC), liver function tests (LFT), folate levels regularly